RATES OF FITNESS DECLINE AND REBOUND SUGGEST PERVASIVE EPISTASIS

@inproceedings{Perfeito2014RATESOF,
  title={RATES OF FITNESS DECLINE AND REBOUND SUGGEST PERVASIVE EPISTASIS},
  author={L{\'i}lia Perfeito and Ana S{\'a} Sousa and Thomas Bataillon and Isabel Gordo},
  booktitle={Evolution; international journal of organic evolution},
  year={2014}
}
Unraveling the factors that determine the rate of adaptation is a major question in evolutionary biology. One key parameter is the effect of a new mutation on fitness, which invariably depends on the environment and genetic background. The fate of a mutation also depends on population size, which determines the amount of drift it will experience. Here, we manipulate both population size and genotype composition and follow adaptation of 23 distinct Escherichia coli genotypes. These have… CONTINUE READING
Highly Cited
This paper has 28 citations. REVIEW CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 17 citations

References

Publications referenced by this paper.
Showing 1-10 of 11 references

The causes of epistasis

  • J. W. Drake
  • Proc . R . Soc . B : Biol . Sci .
  • 2011

The evolution of epistasis and its links with genetic robustness , complexity and drift in a phenotypic model of adaptation

  • J. B. S. Haldane
  • Genetics
  • 2009

Estimate of the genomic mutation rate deleterious to overall fitness in E . coli

  • M. Kimura
  • Nature
  • 1996