RASSF2 is a novel K-Ras-specific effector and potential tumor suppressor.

  title={RASSF2 is a novel K-Ras-specific effector and potential tumor suppressor.},
  author={Michele D. Vos and Chad A. Ellis and Candice Elam and Aylin S Ulku and Barbara J. Taylor and Geoffrey J. Clark},
  journal={The Journal of biological chemistry},
  volume={278 30},
Ras proteins regulate a wide range of biological processes by interacting with a broad assortment of effector proteins. Although activated forms of Ras are frequently associated with oncogenesis, they may also provoke growth-antagonistic effects. These include senescence, cell cycle arrest, differentiation, and apoptosis. The mechanisms that underlie these growth-inhibitory activities are relatively poorly understood. Recently, two related novel Ras effectors, NORE1 and RASSF1, have been… CONTINUE READING
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