RASSF1A and DOK1 Promoter Methylation Levels in Hepatocellular Carcinoma, Cirrhotic and Non-Cirrhotic Liver, and Correlation with Liver Cancer in Brazilian Patients

Abstract

Hepatocellular carcinoma (HCC) is the second most common cause of cancer mortality worldwide. Most cases of HCC are associated with cirrhosis related to chronic hepatitis B virus or hepatitis C virus infections. Hypermethylation of promoter regions is the main epigenetic mechanism of gene silencing and has been involved in HCC development. The aim of this… (More)
DOI: 10.1371/journal.pone.0153796

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@inproceedings{Arajo2016RASSF1AAD, title={RASSF1A and DOK1 Promoter Methylation Levels in Hepatocellular Carcinoma, Cirrhotic and Non-Cirrhotic Liver, and Correlation with Liver Cancer in Brazilian Patients}, author={Oscar C. Ara{\'u}jo and A. A. Santa Rosa and Arlete Fernandes and Christian Niel and Cristiane Alves Villela-Nogueira and Vera L{\'u}cia Nunes Pannain and Natalia Motta Araujo}, booktitle={PloS one}, year={2016} }