RAS signaling unleashed in breast cancer

  title={RAS signaling unleashed in breast cancer},
  author={Leslie K. Ferrarelli},
  journal={Science Signaling},
Cancer cells undergo a switch called epithelial-to-mesenchymal transition (EMT) to gain migratory and invasive phenotypes associated with metastasis. Mutations in the guanosine triphosphatase (GTPase) RAS contribute to EMT by disrupting epithelial cell adhesion and polarity. Okada et al. investigated the role of Rho GTPases, members of the RAS superfamily, in breast cancer progression. Bioinformatic analysis of basal-like and triple-negative breast cancers showed that low expression of the gene… CONTINUE READING