RAS function and protein kinase cascades.

@article{Marcus1993RASFA,
  title={RAS function and protein kinase cascades.},
  author={Stevan Marcus and Mike Wigler and Hao Peng Xu and R Y Ballester and Makoto Kawamukai and Anthony J Polverino},
  journal={Ciba Foundation symposium},
  year={1993},
  volume={176},
  pages={53-61; discussion 61-6}
}
This paper reviews recent progress in understanding the function of RAS in three systems: the budding yeast (Saccharomyces cerevisiae), the fission yeast (Schizosaccharomyces pombe) and Xenopus laevis oocytes. One of the functions of RAS in S. cerevisiae is the stimulation of adenylate cyclase. This leads to the activation of the cAMP-dependent protein kinases--a function that has probably not been conserved in evolution. The immediate function of RAS in S. pombe is not known, but it may lead… CONTINUE READING

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