RAS and leukemia: from basic mechanisms to gene-directed therapy.

  title={RAS and leukemia: from basic mechanisms to gene-directed therapy.},
  author={Darrin M. Beaupre and Razelle Kurzrock},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  volume={17 3},
PURPOSE AND DESIGN The purpose of this review is to provide an overview of the literature linking Ras signaling pathways and leukemia and to discuss the biologic and potential therapeutic implications of these observations. A search of MEDLINE from 1966 to October 1998 was performed. RESULTS A wealth of data has been published on the role of Ras pathways in cancer. To be biologically active, Ras must move from the cytoplasm to the plasma membrane. Importantly, a posttranslational modification… CONTINUE READING