RAS Mutations in Human Cancers: Roles in Precision Medicine.

@article{Murugan2019RASMI,
  title={RAS Mutations in Human Cancers: Roles in Precision Medicine.},
  author={Avaniyapuram Kannan Murugan and Michele Grieco and Nobuo Tsuchida},
  journal={Seminars in cancer biology},
  year={2019}
}

Emerging RAS-directed therapies for cancer

TLDR
A review summarizes the diverse approaches that have been taken to RAS inhibition and then focuses on the most recent developments in direct inhibition of KRAS(G12C), which carries much promise.

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TLDR
It is concluded that a significant body of evidence supports a leading role rather than a supporting (or secondary) role for K-RAS4A in cancer biology.

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TLDR
It is demonstrated that RASSF1A upregulates DAB2IP protein levels in NSCLC cells and presents the first mechanistic evidence for control of RAS activation by RASSf1A.

A Driver Never Works Alone—Interplay Networks of Mutant p53, MYC, RAS, and Other Universal Oncogenic Drivers in Human Cancer

TLDR
This review focuses on representative examples of the interaction of major oncogenic drivers with one another and selects the drivers with the highest frequency of known activation in human neoplasia.

Targeting RAS in neuroblastoma: Is it possible?

Oncogenic KRAS blockade therapy: renewed enthusiasm and persistent challenges

TLDR
The mutations and functions of KRAS in human tumors are outlined and then indirect and direct approaches to shut down the oncogenic KRAS network are analyzed, including mechanistic principles, clinical features, and strategies for overcoming primary or secondary resistance to KRAS-G12C blockade.

Gene Therapy Targeting p53 and KRAS for Colorectal Cancer Treatment: A Myth or the Way Forward?

TLDR
The potentials and challenges of gene therapy targeting p53 and KRAS for the treatment of CRC are reviewed, which potentially serves as an alternative treatment avenue for the disease in addition to the standard therapy.

Targeting Mutated KRAS Genes to Treat Solid Tumours.

TLDR
The importance of mutant KRAS in solid tumours, prior attempts at inhibiting mutantKRAS, and the current promising targeted agents being investigated in clinical trials are summarized, along with future challenges.

Targeting Aberrant RAS/RAF/MEK/ERK Signaling for Cancer Therapy

TLDR
The recent major findings in the study of the RAS/RAF/MEK/ERK signaling cascade are summarized, particularly with respect to the impact on clinical cancer therapy.
...

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