RAS-Mediated radiation resistance is not linked to MAP kinase activation in two bladder carcinoma cell lines.

@article{Gupta2000RASMediatedRR,
  title={RAS-Mediated radiation resistance is not linked to MAP kinase activation in two bladder carcinoma cell lines.},
  author={Anjali K. Gupta and Eric J. Bernhard and Vincent J. Bakanauskas and Joseph M.W. Wu and Ruth J. Muschel and W. Gillies Mckenna},
  journal={Radiation research},
  year={2000},
  volume={154 1},
  pages={
          64-72
        }
}
The expression of activated RAS oncogenes has been shown to increase radioresistance in a number of cell lines. The pathways by which RAS leads to radioresistance, however, are unknown. RAS activates several signal transduction pathways, with the RAF-MAP2K-MAP kinase pathway perhaps the best studied. MAP kinase has also been shown to be activated by radiation through this pathway. Given the important role of MAP kinase in multiple signaling events, we asked if radioresistance induced by RAS was… CONTINUE READING
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