RARA fusion genes in acute promyelocytic leukemia: a review.

Abstract

The t(15;17)(q24;q21), generating a PML-RARA fusion gene, is the hallmark of acute promyelocytic leukemia (APL). At present, eight other genes fusing with RARA have been identified. The resulting fusion proteins retain domains of the RARA protein allowing binding to retinoic acid response elements (RARE) and dimerization with the retinoid X receptor protein… (More)
DOI: 10.1586/17474086.2014.903794

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Cite this paper

@article{Braekeleer2014RARAFG, title={RARA fusion genes in acute promyelocytic leukemia: a review.}, author={Etienne de Braekeleer and Nathalie Douet-Guilbert and Marc de Braekeleer}, journal={Expert review of hematology}, year={2014}, volume={7 3}, pages={347-57} }