RAPID COMMUNICATION Monoclonal Nature of Transient Abnormal Myelopoiesis in Down’s Syndrome

Abstract

Neonates with Down’s syndrome occasionally show an excess of blasts in their peripheral blood. This disorder spontaneously resolves within several months and is called transient abnormal myelopoiesis (TAM) or transient myeloproliferative disorder. It has been uncertain whether the excess of blasts in TAM is a result of a clonal proliferation or a polyclonal reactive condition. The clonality of cells in females can be examined by analysis of the methylation patterns of the X chromosomes of proliferating cells using restriction fragment length polymorphism (RFLP). Using this strategy, we studied three females with Down’s syndrome accompa-

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Cite this paper

@inproceedings{Kurahashi2003RAPIDCM, title={RAPID COMMUNICATION Monoclonal Nature of Transient Abnormal Myelopoiesis in Down’s Syndrome}, author={Hiroki Kurahashi and Junichi Hara and Keiko Yumura-Yagi and Norihide Murayama and Masami Inoue and Shigehiko Ishihara and Akio Tawa and Shintaro Okada}, year={2003} }