RANTES stimulates inflammatory cascades and receptor modulation in murine astrocytes.

@article{Luo2002RANTESSI,
  title={RANTES stimulates inflammatory cascades and receptor modulation in murine astrocytes.},
  author={Yi Luo and Michael A. Berman and Qiwei Zhai and Falko R. Fischer and Sara R Abromson-Leeman and Yingjie Zhang and William A. Kuziel and Craig Gerard and Martin E Dorf},
  journal={Glia},
  year={2002},
  volume={39 1},
  pages={19-30}
}
Cultured mouse astrocytes respond to the CC chemokine RANTES by production of chemokine and cytokine transcripts. Stimulation of astrocytes with 1 nM RANTES or 3-10 nM of the structurally related chemokines (eotaxin, macrophage inflammatory protein-1alpha and -beta [MIP-1alpha, MIP-1beta]) induced transcripts for KC, monocyte chemoattractant protein-1 (MCP-1), tumor necrosis factor-alpha (TNF-alpha), MIP-1alpha, MIP-2, and RANTES in a chemokine and cell-specific fashion. Synthesis of chemokine… CONTINUE READING
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