RANTES and human sperm fertilizing ability: effect on acrosome reaction and sperm/oocyte fusion.

@article{Barbonetti2008RANTESAH,
  title={RANTES and human sperm fertilizing ability: effect on acrosome reaction and sperm/oocyte fusion.},
  author={Arcangelo Barbonetti and Maria Rosaria Caterina Vassallo and C. Antonangelo and Valeria Nuccetelli and Anatolia d'Angeli and Fiore Pelliccione and Mauro Giorgi and F. Francavilla and Sandro Francavilla},
  journal={Molecular human reproduction},
  year={2008},
  volume={14 7},
  pages={
          387-91
        }
}
Beta-chemokine, regulated on activation and normally T-cell expressed and presumably secreted (RANTES), is present in both the male and female genital tract fluids where its levels increase in diseases related to infertility, such as endometriosis and male genital tract infections. beta-Chemokine receptors (CCR3 and CCR5) are expressed on freshly ejaculated human sperm cells and a sperm chemoattractant effect for RANTES has been reported. No information exists on other possible roles of RANTES… 
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Findings of the present study suggest that CCR6-CCL20 interaction may represent an important factor in directing sperm–oocyte interaction.
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TLDR
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In vitro exposure of human spermatozoa to bisphenol A induces pro-oxidative/apoptotic mitochondrial dysfunction.
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This study built the first protein interaction network of human sperm-egg binding and fusion proteins that consists of 84 protein nodes and 112 interactions and showed that the ADAM2 may mediate interaction between two essential factors CD9 and IZUMO1.
Pathophysiological factors and genetic association in endometriosis
TLDR
A strong inflammatory component in endometriosis is found, which may affect the ovarian reserve and lead to infertility problems and may at least partly be regulated by inflammatory mediators.
The effects of an in utero exposure to 2,3,7,8-tetrachloro-dibenzo-p-dioxin on male reproductive function: identification of Ccl5 as a potential marker
TLDR
A decrease in Ccl5/Rantes RNA levels and a transitory decline in sperm reserves in the testes of rats of TCDD-dosed dams is demonstrated.
Endometriosis and infertility: pathophysiology and management
Endometriosis‐Associated Infertility: Double Intrauterine Insemination Improves Fecundity in Patients Positive for Antiendometrial Antibodies
TLDR
Endometriosis‐associated infertility: double intrauterine insemination improves fecundity in patients positive for antiendometrial antibodies.
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