RANKL subcellular trafficking and regulatory mechanisms in osteocytes.

@article{Honma2013RANKLST,
  title={RANKL subcellular trafficking and regulatory mechanisms in osteocytes.},
  author={Masashi Honma and Yuki Ikebuchi and Yoshiaki Kariya and Madoka Hayashi and Naoki Hayashi and Shigeki Aoki and Hiroshi Kubiki Suzuki},
  journal={Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  year={2013},
  volume={28 9},
  pages={
          1936-49
        }
}
The receptor activator of the NF-κB ligand (RANKL) is the central player in the regulation of osteoclastogenesis, and the quantity of RANKL presented to osteoclast precursors is an important factor determining the magnitude of osteoclast formation. Because osteoblastic cells are thought to be a major source of RANKL, the regulatory mechanisms of RANKL subcellular trafficking have been studied in osteoblastic cells. However, recent reports showed that osteocytes are a major source of RANKL… CONTINUE READING
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  • Journal of Bone and Mineral Metabolism
  • 2013
VIEW 10 EXCERPTS
CITES BACKGROUND & METHODS
HIGHLY INFLUENCED

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  • JBMR plus
  • 2018
VIEW 1 EXCERPT
CITES BACKGROUND

References

Publications referenced by this paper.
SHOWING 1-10 OF 33 REFERENCES

Rab27a and Rab27b are involved in stimulation-dependent RANKL release from secretory lysosomes in osteoblastic cells.

  • Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
  • 2011
VIEW 7 EXCERPTS
HIGHLY INFLUENTIAL

The Amazing Osteocyte

  • Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
  • 2011
VIEW 20 EXCERPTS
HIGHLY INFLUENTIAL

Function of OPG as a traffic regulator for RANKL is crucial for controlled osteoclastogenesis.

  • Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
  • 2010
VIEW 11 EXCERPTS
HIGHLY INFLUENTIAL

Dynamics of the transition from osteoblast to osteocyte.

  • Annals of the New York Academy of Sciences
  • 2010
VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL

Vps33a mediates RANKL storage in secretory lysosomes in osteoblastic cells.

  • Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
  • 2009
VIEW 6 EXCERPTS
HIGHLY INFLUENTIAL

Cellular communications in bone homeostasis and repair

  • Cellular and Molecular Life Sciences
  • 2010
VIEW 2 EXCERPTS

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