RANKL regulates differentiation of microfold cells in mouse nasopharynx-associated lymphoid tissue (NALT)

@article{Mutoh2015RANKLRD,
  title={RANKL regulates differentiation of microfold cells in mouse nasopharynx-associated lymphoid tissue (NALT)},
  author={Mami Mutoh and Shunsuke Kimura and Hiromi Takahashi-Iwanaga and Meri Hisamoto and Toshihiko Iwanaga and Junichiro Iida},
  journal={Cell and Tissue Research},
  year={2015},
  volume={364},
  pages={175-184}
}
Murine nasopharynx-associated lymphoid tissue (NALT), located at the base of the nasal cavity, serves as a major site for the induction of mucosal immune responses against airway antigens. The follicle-associated epithelium (FAE) covering the luminal surface of NALT is characterized by the presence of microfold cells (M cells), which take up and transport luminal antigens to lymphocytes. Glycoprotein 2 (GP2) has recently been identified as a reliable marker for M cells in Peyer’s patches of the… CONTINUE READING

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Visualization of the entire differentiation process of murine M cells: suppression of their maturation in cecal patches

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