RANKL promotes osteoblastic activity in vascular smooth muscle cells by upregulating endothelial BMP-2 release.

@article{Davenport2016RANKLPO,
  title={RANKL promotes osteoblastic activity in vascular smooth muscle cells by upregulating endothelial BMP-2 release.},
  author={Colin Davenport and Emma Harper and Hannah Elizabeth Forde and Keith D. Rochfort and Ronan P. Murphy and Diarmuid Smith and Philip M Cummins},
  journal={The international journal of biochemistry & cell biology},
  year={2016},
  volume={77 Pt A},
  pages={
          171-180
        }
}
INTRODUCTION Receptor activator of nuclear factor kappa beta-ligand (RANKL) is thought to promote vascular calcification (VC) by inducing osteoblastic behaviour in vascular smooth muscle cells (VSMC) in an ill-defined process. The present study assessed whether RANKL affects pro-osteoblastic paracrine signalling between human aortic endothelial cells (HAEC) and human aortic smooth muscle cells (HASMC) using both conditioned media transfer and cell co-culture experimental approaches. METHODS… CONTINUE READING