RANKL expression in normal and malignant breast tissue responds to progesterone and is up-regulated during the luteal phase

@article{Hu2014RANKLEI,
  title={RANKL expression in normal and malignant breast tissue responds to progesterone and is up-regulated during the luteal phase},
  author={Hong Hu and J. Wang and Akash Gupta and A. Shidfar and D. Branstetter and O. Lee and D. Ivancic and M. Sullivan and R. Chatterton and W. Dougall and Seema A. Khan},
  journal={Breast Cancer Research and Treatment},
  year={2014},
  volume={146},
  pages={515-523}
}
The receptor activator of nuclear factor-κB ligand (RANKL) acts as a paracrine factor in progesterone-induced mammary epithelial proliferation and tumorigenesis. This evidence comes mainly from mouse models. Our aim was to examine whether RANKL expression in human normal and malignant breast is under the control of progesterone throughout the menstrual cycle. Breast epithelial samples were obtained by random fine needle aspiration (rFNA) of the contralateral unaffected breasts (CUB) of 18… Expand
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