RANKL directly induces bone morphogenetic protein-2 expression in RANK-expressing POS-1 osteosarcoma cells.

@article{Wittrant2006RANKLDI,
  title={RANKL directly induces bone morphogenetic protein-2 expression in RANK-expressing POS-1 osteosarcoma cells.},
  author={Yohann Wittrant and François Lamoureux and Kanji Mori and A. M. Riet and Akira Kamijo and Dominique Heymann and Françoise R{\'e}din{\'i}},
  journal={International journal of oncology},
  year={2006},
  volume={28 1},
  pages={261-9}
}
The POS-1 murine model of osteolytic osteosarcoma was used to elucidate the molecular and cellular mechanisms involved in the development of primary bone tumors and associated lung metastasis. The POS-1 cell line is derived from an osteosarcoma tumor which develops spontaneously in C3H mice. The POS-1 cell line was characterized in vitro by mineralization capacity and expression of bone markers by semi-quantitative RT-PCR, compared to primary osteoblasts and bone marrow cells. POS-1 cells… CONTINUE READING

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