RANKL Expression in Periodontal Disease: Where Does RANKL Come from?

@inproceedings{Chen2014RANKLEI,
  title={RANKL Expression in Periodontal Disease: Where Does RANKL Come from?},
  author={Bin Chen and Wenlei Wu and Wei-bin Sun and Qian Zhang and Fuhua Yan and Yin Xiao},
  booktitle={BioMed research international},
  year={2014}
}
Periodontitis is an inflammatory disease characterized by periodontal pocket formation and alveolar bone resorption. Periodontal bone resorption is induced by osteoclasts and receptor activator of nuclear factor-κB ligand (RANKL) which is an essential and central regulator of osteoclast development and osteoclast function. Therefore, RANKL plays a critical role in periodontal bone resorption. In this review, we have summarized the sources of RANKL in periodontal disease and explored which… CONTINUE READING
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