RANKL/RANK - from bone physiology to breast cancer.

  title={RANKL/RANK - from bone physiology to breast cancer.},
  author={Verena Sigl and Josef M. Penninger},
  journal={Cytokine & growth factor reviews},
  volume={25 2},
RANK and its ligand RANKL are key molecules in bone metabolism and are critically involved in pathologic bone disorders. Deregulation of the RANK/RANKL system is for example a main reason for the development of postmenopausal osteoporosis, which affects millions of women worldwide. Another essential function of RANK and RANKL is the development of a functional lactating mammary gland during pregnancy. Sex hormones, in particular progesterone, induce RANKL expression resulting in proliferation… CONTINUE READING