RANKL/RANK/OPG: new therapeutic targets in bone tumours and associated osteolysis.

  title={RANKL/RANK/OPG: new therapeutic targets in bone tumours and associated osteolysis.},
  author={Yohann Wittrant and Sandrine Th{\'e}oleyre and C{\'e}line Chipoy and Marc Padrines and Fr{\'e}d{\'e}ric Blanchard and Dominique Heymann and Françoise R{\'e}din{\'i}},
  journal={Biochimica et biophysica acta},
  volume={1704 2},
The emergence of the molecular triad osteoprotegerin (OPG)/Receptor Activator of NF-kB (RANK)/RANK Ligand (RANKL) has helped elucidate a key signalling pathway between stromal cells and osteoclasts. The interaction between RANK and RANKL plays a critical role in promoting osteoclast differentiation and activation leading to bone resorption. OPG is a soluble decoy receptor for RANKL that blocks osteoclast formation by inhibiting RANKL binding to RANK. The OPG/RANK/RANKL system has been shown to… CONTINUE READING
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