RANKL/RANK/OPG: new therapeutic targets in bone tumours and associated osteolysis.

@article{Wittrant2004RANKLRANKOPGNT,
  title={RANKL/RANK/OPG: new therapeutic targets in bone tumours and associated osteolysis.},
  author={Yohann Wittrant and Sandrine Th{\'e}oleyre and C{\'e}line Chipoy and Marc Padrines and Fr{\'e}d{\'e}ric Blanchard and Dominique Heymann and Françoise R{\'e}din{\'i}},
  journal={Biochimica et biophysica acta},
  year={2004},
  volume={1704 2},
  pages={49-57}
}
The emergence of the molecular triad osteoprotegerin (OPG)/Receptor Activator of NF-kB (RANK)/RANK Ligand (RANKL) has helped elucidate a key signalling pathway between stromal cells and osteoclasts. The interaction between RANK and RANKL plays a critical role in promoting osteoclast differentiation and activation leading to bone resorption. OPG is a soluble decoy receptor for RANKL that blocks osteoclast formation by inhibiting RANKL binding to RANK. The OPG/RANK/RANKL system has been shown to… CONTINUE READING
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References

Publications referenced by this paper.
Showing 1-10 of 68 references

Cancer and bone.

Endocrine reviews • 1998
View 4 Excerpts
Highly Influenced

Expression of osteoclast differentiation signals by stromal elements of giant cell tumors.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research • 2000
View 7 Excerpts
Highly Influenced

A phase I study of AMGN-0007, a recombinant osteoprotegerin construct, in patients with multiple myeloma or breast carcinoma related bone metastases

P J Dunstan, Bekker
Cancer • 2003

Differences in the cytokine profiles associated with prostate cancer cell induced osteoblastic and osteolytic lesions in bone.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society • 2003
View 1 Excerpt

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