RANK-mediated amplification of TRAF6 signaling leads to NFATc1 induction during osteoclastogenesis.

@article{Gohda2005RANKmediatedAO,
  title={RANK-mediated amplification of TRAF6 signaling leads to NFATc1 induction during osteoclastogenesis.},
  author={Jin Gohda and Toru Akiyama and Takako Koga and Hiroshi Takayanagi and Sakae Tanaka and Jun-Ichiro Inoue},
  journal={The EMBO journal},
  year={2005},
  volume={24 4},
  pages={790-9}
}
RANK and CD40 activate NF-kappaB and MAPKs to similar levels via TRAF6. Even though overexpression of TRAF6 results in osteoclast formation, RANK but not CD40 promotes osteoclastogenesis. To understand the molecular basis for RANK-specific activity in osteoclastogenesis, we created an osteoclast formation system driven by anti-human CD40 antibody-mediated stimulation of a chimeric receptor, h40/mRK, which consists of the extracellular domain of human CD40 and the transmembrane and cytoplasmic… CONTINUE READING

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