RANK ligand-induced elevation of cytosolic Ca2+ accelerates nuclear translocation of nuclear factor kappa B in osteoclasts.

@article{Komarova2003RANKLE,
  title={RANK ligand-induced elevation of cytosolic Ca2+ accelerates nuclear translocation of nuclear factor kappa B in osteoclasts.},
  author={Svetlana V. Komarova and Mary F. Pilkington and A Frederik Weidema and S. Jeffrey Dixon and Stephen Michael Sims},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 10},
  pages={8286-93}
}
RANK ligand (RANKL) induces activation of NFkappaB, enhancing the formation, resorptive activity, and survival of osteoclasts. Ca(2+) transduces many signaling events, however, it is not known whether the actions of RANKL involve Ca(2+) signaling. We investigated the effects of RANKL on rat osteoclasts using microspectrofluorimetry and patch clamp. RANKL induced transient elevation of cytosolic free Ca(2+) concentration ([Ca(2+)](i)) to maxima 220 nm above basal, resulting in activation of Ca(2… CONTINUE READING

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