RANK ligand as a potential target for breast cancer prevention in BRCA1-mutation carriers

@article{Nolan2016RANKLA,
  title={RANK ligand as a potential target for breast cancer prevention in BRCA1-mutation carriers},
  author={Emma Nolan and François Vaillant and Daniel G. Branstetter and B Pal and G{\"o}knur Giner and Lachlan W Whitehead and Sheau Wen Lok and Gregory B Mann and Kathy Rohrbach and Li-Ya Huang and Rosalia Soriano and Gordon K Smyth and William C Dougall and Jane E. Visvader and Geoffrey J Lindeman},
  journal={Nature Medicine},
  year={2016},
  volume={22},
  pages={933-939}
}
Individuals who have mutations in the breast-cancer-susceptibility gene BRCA1 (hereafter referred to as BRCA1-mutation carriers) frequently undergo prophylactic mastectomy to minimize their risk of breast cancer. The identification of an effective prevention therapy therefore remains a 'holy grail' for the field. Precancerous BRCA1mut/+ tissue harbors an aberrant population of luminal progenitor cells, and deregulated progesterone signaling has been implicated in BRCA1-associated oncogenesis… CONTINUE READING
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