RANK Signaling Amplifies WNT-Responsive Mammary Progenitors through R-SPONDIN1

  title={RANK Signaling Amplifies WNT-Responsive Mammary Progenitors through R-SPONDIN1},
  author={P. Hayes A. Joshi and Paul Waterhouse and Nagarajan Kannan and Swami R Narala and Hui Fang and Marco A. Di Grappa and Hartland W. Jackson and Josef M. Penninger and Connie J. Eaves and Rama Khokha},
  booktitle={Stem cell reports},
Systemic and local signals must be integrated by mammary stem and progenitor cells to regulate their cyclic growth and turnover in the adult gland. Here, we show RANK-positive luminal progenitors exhibiting WNT pathway activation are selectively expanded in the human breast during the progesterone-high menstrual phase. To investigate underlying mechanisms, we examined mouse models and found that loss of RANK prevents the proliferation of hormone receptor-negative luminal mammary progenitors and… CONTINUE READING
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