RANK(L) as a key target for controlling bone loss.

  title={RANK(L) as a key target for controlling bone loss.},
  author={Andreas Leibbrandt and Josef M. Penninger},
  journal={Advances in experimental medicine and biology},
Bone-related diseases, such as osteoporosis or rheumatoid arthritis, affect hundreds of millions of people worldwide and pose a tremendous burden to health care. By deepening our understanding of the molecular mechanisms of bone metabolism and bone turnover, it became possible over the past years to devise new and promising strategies for treating such diseases. In particular, three molecules, the receptor activator of NF-kappaB(RANK), its ligand RANKL and the decoy receptor of RANKL… CONTINUE READING


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