RANDOMISED CONTROLLED TRIAL OF GENETIC AMNIOCENTESIS IN 4606 LOW-RISK WOMEN

@article{Tabor1986RANDOMISEDCT,
  title={RANDOMISED CONTROLLED TRIAL OF GENETIC AMNIOCENTESIS IN 4606 LOW-RISK WOMEN},
  author={Ann Tabor and Mette Madsen and Erik Bernhard Obel and John Philip and Jens Bang and BentN{\o}r Gaard-Pedersen},
  journal={The Lancet},
  year={1986},
  volume={327},
  pages={1287-1293}
}
Outcome of pregnancy after amniocentesis was studied in a randomised controlled trial of 4606 women, age-range 25-34 years, without known risk of genetic disease. Spontaneous abortion rate was 1.7% in the study group after amniocentesis and 0.7% in the control group after ultrasound (relative risk 2.3). In the study group, increased levels of maternal serum alpha-fetoprotein before amniocentesis, perforation of the placenta during amniocentesis, and withdrawal of discoloured amniotic fluid were… 
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The procedure-related fetal loss rate after midtrimester amniocentesis performed on patients in a contemporary prospective clinical trial was 0.06%, and there was no significant difference in loss rates between those undergoing amziocentesis and those not undergoing amNIocentesis.
Mid-trimester genetic amniocentesis in twin pregnancy and the risk of fetal loss.
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Amniocentesis in women with twin pregnancies increased the risk of fetal losses prior to 20 to 24 weeks' gestation with an additional risk of one adverse outcome (1 or 2 fetal losses) for every 64 amniocenteses.
Uterine fibroids and risk for complications following second-trimester amniocentesis.
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TLDR
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