RAN/TC4 mutants identify a common requirement for snRNP and protein import into the nucleus

@article{Palacios1996RANTC4MI,
  title={RAN/TC4 mutants identify a common requirement for snRNP and protein import into the nucleus},
  author={I Palacios and Karsten Weis and Christian Klebe and Iain W Mattaj and Colin Dingwall},
  journal={The Journal of Cell Biology},
  year={1996},
  volume={133},
  pages={485 - 494}
}
Kinetic competition experiments have demonstrated that at least some factors required for the nuclear import of proteins and U snRNPs are distinct. Both import processes require energy, and in the case of protein import, the energy requirement is known to be at least partly met by GTP hydrolysis by the Ran GTPase. We have compared the effects of nonhydrolyzable GTP analogues and two mutant Ran proteins on the nuclear import of proteins and U snRNPs in vitro. The mutant Ran proteins have… CONTINUE READING

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