RAM-induced allostery facilitates assembly of a notch pathway active transcription complex.

@article{Friedmann2008RAMinducedAF,
  title={RAM-induced allostery facilitates assembly of a notch pathway active transcription complex.},
  author={David R Friedmann and Jeffrey J. Wilson and Rhett A. Kovall},
  journal={The Journal of biological chemistry},
  year={2008},
  volume={283 21},
  pages={14781-91}
}
The Notch pathway is a conserved cell-to-cell signaling mechanism, in which extracellular signals are transduced into transcriptional outputs through the nuclear effector CSL. CSL is converted from a repressor to an activator through the formation of the CSL-NotchIC-Mastermind ternary complex. The RAM (RBP-J associated molecule) domain of NotchIC avidly interacts with CSL; however, its role in assembly of the CSL-NotchIC-Mastermind ternary complex is not understood. Here we provide a… CONTINUE READING