RAGE mediates the inactivation of nAChRs in sympathetic neurons under high glucose conditions.

@article{Chandna2015RAGEMT,
  title={RAGE mediates the inactivation of nAChRs in sympathetic neurons under high glucose conditions.},
  author={Andrew R Chandna and Manoj Kumar Bhaskaran Nair and Christine N Chang and Paul R. Pennington and Yasuhiko Yamamoto and Darrell D. Mousseau and Ver{\'o}nica A Campanucci},
  journal={The European journal of neuroscience},
  year={2015},
  volume={41 3},
  pages={341-51}
}
Autonomic dysfunction is a serious complication of diabetes and can lead to cardiovascular abnormalities and premature death. It was recently proposed that autonomic dysfunction is triggered by oxidation-mediated inactivation of neuronal nicotinic acetylcholine receptors (nAChRs), impairing synaptic transmission in sympathetic ganglia and resulting in… CONTINUE READING