RAGE mediates amyloid-β peptide transport across the blood-brain barrier and accumulation in brain


Amyloid-β peptide (Aβ) interacts with the vasculature to influence Aβ levels in the brain and cerebral blood flow, providing a means of amplifying the Aβ-induced cellular stress underlying neuronal dysfunction and dementia. Systemic Aβ infusion and studies in genetically manipulated mice show that Aβ interaction with receptor for advanced glycation end… (More)
DOI: 10.1038/nm890


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