RAGE ligands induce apoptotic cell death of pancreatic β-cells via oxidative stress.

  title={RAGE ligands induce apoptotic cell death of pancreatic β-cells via oxidative stress.},
  author={Byung Wan Lee and Hee Young Chae and Soo Jin Kwon and So Youn Park and Jahei Ihm and S Ihm},
  journal={International journal of molecular medicine},
  volume={26 6},
Activation of the receptor for advanced glycation endproducts (RAGE) by its ligands leads to cellular damage contributing to diabetic complications. It is not clearly known whether RAGE ligands influence pancreatic β-cells. In this study, we investigated the expression of RAGE in islet cells and the effect of RAGE ligands, S100b and HMG-1, on islet cells. RAGE was expressed in INS-1 cells and isolated rat and human islets at mRNA and protein levels. RAGE and its ligand, S100b, were detected on… CONTINUE READING


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