RAGE drives the development of glomerulosclerosis and implicates podocyte activation in the pathogenesis of diabetic nephropathy.

@article{Wendt2003RAGEDT,
  title={RAGE drives the development of glomerulosclerosis and implicates podocyte activation in the pathogenesis of diabetic nephropathy.},
  author={Thoralf M Wendt and Nozomu Tanji and Jiancheng Guo and Thomas Kislinger and Wu Qu and Yan Lu and Loredana G. Bucciarelli and Ling Ling Rong and Bernhard Moser and Glen S. Markowitz and Gunther Stein and Angelika Bierhaus and Birgit Liliensiek and Bernd Arnold and Peter P Nawroth and David M. Stern and Vivette D D'agati and Ann Marie Schmidt},
  journal={The American journal of pathology},
  year={2003},
  volume={162 4},
  pages={1123-37}
}
Diabetic nephropathy ensues from events involving earliest changes in the glomeruli and podocytes, followed by accumulation of extracellular matrix in the mesangium. Postulated mechanisms include roles for vascular endothelial growth factor (VEGF), produced by podocytes and contributing to enhanced excretion of urinary albumin and recruitment/activation of inflammatory cells, and transforming growth factor-beta (TGF-beta), elicited largely from mesangial cells and driving production of… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 243 extracted citations

Similar Papers

Loading similar papers…