RAGE and amyloid beta interactions : Atomic force microscopy and molecular modeling

@inproceedings{Chaneya2005RAGEAA,
  title={RAGE and amyloid beta interactions : Atomic force microscopy and molecular modeling},
  author={Michael O. Chaneya and W. Blaine Stineb and Tyler A. Kokjohnc and Yu-Min Kuod and Chera Eshe and Afroza Rahmane and Dean C. Luehrse and Ann Marie Schmidtf and David Sterng and Shi Du Yanf and Alex E. Rohere},
  year={2005}
}
  • Michael O. Chaneya, W. Blaine Stineb, +8 authors Alex E. Rohere
  • Published 2005
In the AD brain, there are elevated amounts of soluble and insoluble Ah peptides which enhance the expression of membrane bound and soluble receptor for advanced glycation end products (RAGE). The binding of soluble Ah to soluble RAGE inhibits further aggregation of Ah peptides, while membrane bound RAGE-Ah interactions elicit activation of the NF-nB transcription factor promoting sustained chronic neuroinflammation. Atomic force microscopy observations demonstrated that the N-terminal domain… CONTINUE READING