RAGE Modulates Hypoxia/Reoxygenation Injury in Adult Murine Cardiomyocytes via JNK and GSK-3β Signaling Pathways

@inproceedings{Shang2010RAGEMH,
  title={RAGE Modulates Hypoxia/Reoxygenation Injury in Adult Murine Cardiomyocytes via JNK and GSK-3β Signaling Pathways},
  author={Linshan Shang and Radha Ananthakrishnan and Qing Li and Nosirudeen Quadri and Mariane L Abdillahi and Zhengbin Zhu and Wu Qu and Rosa H Rosario and Fatouma Tour{\'e} and Shi Fang Yan and Ann Marie Schmidt and Ravichandran Ramasamy},
  booktitle={PloS one},
  year={2010}
}
BACKGROUND Advanced glycation end-products (AGEs) have been implicated in diverse pathological settings including diabetes, inflammation and acute ischemia/reperfusion injury in the heart. AGEs interact with the receptor for AGEs (RAGE) and transduce signals through activation of MAPKs and proapoptotic pathways. In the current study, adult cardiomyocytes were studied in an in vitro ischemia/reperfusion (I/R) injury model to delineate the molecular mechanisms underlying RAGE-mediated injury due… CONTINUE READING

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