RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement.

@article{Shinkai1992RAG2deficientML,
  title={RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement.},
  author={Yoichi Shinkai and Gary A. Rathbun and Kong Peng Lam and Eugene M. Oltz and V. Stewart and Monica M. Mendelsohn and Jean Charron and Mandrita Datta and Faith Young and Alan M. Stall},
  journal={Cell},
  year={1992},
  volume={68 5},
  pages={855-67}
}
We have generated mice that carry a germline mutation in which a large portion of the RAG-2 coding region is deleted. Homozygous mutants are viable but fail to produce mature B or T lymphocytes. Very immature lymphoid cells were present in primary lymphoid organs of mutant animals as defined by surface marker analyses and Abelson murine leukemia virus (A-MuLV) transformation assays. However, these cells did not rearrange their immunoglobulin or T cell receptor loci. Lack of V(D)J recombination… CONTINUE READING
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