RAG-1 interacts with the repeated amino acid motif of the human homologue of the yeast protein SRP1.

@article{Corts1994RAG1IW,
  title={RAG-1 interacts with the repeated amino acid motif of the human homologue of the yeast protein SRP1.},
  author={Patricia P{\'e}rez Cort{\'e}s and Zaiming Sam Ye and David Baltimore},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1994},
  volume={91 16},
  pages={
          7633-7
        }
}
Genes for immunoglobulins and T-cell receptor are generated by a process known as V(D)J recombination. This process is highly regulated and mediated by the recombination activating proteins RAG-1 and RAG-2. By the use of the two-hybrid protein interaction system, we isolated a human protein that specifically interacts with RAG-1. This protein is the human homologue of the yeast SRP1 (suppressor of a temperature-sensitive RNA polymerase I mutation). The SRP1-1 mutation is an allele-specific… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 71 CITATIONS, ESTIMATED Infinity% COVERAGE

71 Citations

0246'95'00'06'12'18
Citations per Year
Semantic Scholar estimates that this publication has 71 citations based on the available data.

See our FAQ for additional information.

Similar Papers

Loading similar papers…