RAF protein-serine/threonine kinases: structure and regulation.

  title={RAF protein-serine/threonine kinases: structure and regulation.},
  author={Robert Roskoski},
  journal={Biochemical and biophysical research communications},
  volume={399 3},
A-RAF, B-RAF, and C-RAF are a family of three protein-serine/threonine kinases that participate in the RAS-RAF-MEK-ERK signal transduction cascade. This cascade participates in the regulation of a large variety of processes including apoptosis, cell cycle progression, differentiation, proliferation, and transformation to the cancerous state. RAS mutations occur in 15-30% of all human cancers, and B-RAF mutations occur in 30-60% of melanomas, 30-50% of thyroid cancers, and 5-20% of colorectal… CONTINUE READING
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