RAF protein-serine/threonine kinases: structure and regulation.

@article{Roskoski2010RAFPK,
  title={RAF protein-serine/threonine kinases: structure and regulation.},
  author={Robert Roskoski},
  journal={Biochemical and biophysical research communications},
  year={2010},
  volume={399 3},
  pages={313-7}
}
A-RAF, B-RAF, and C-RAF are a family of three protein-serine/threonine kinases that participate in the RAS-RAF-MEK-ERK signal transduction cascade. This cascade participates in the regulation of a large variety of processes including apoptosis, cell cycle progression, differentiation, proliferation, and transformation to the cancerous state. RAS mutations occur in 15-30% of all human cancers, and B-RAF mutations occur in 30-60% of melanomas, 30-50% of thyroid cancers, and 5-20% of colorectal… CONTINUE READING
68 Citations
28 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 68 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 28 references

I

  • G. Hatzivassiliou, K. Song
  • Yen, et al., RAF inhibitors prime wild-type RAF…
  • 2010
3 Excerpts

S

  • S. J. Heidorn, C. Milagre
  • Whittaker, et al., Kinase-dead BRAF and oncogenic…
  • 2010
2 Excerpts

Similar Papers

Loading similar papers…