RAD9 and RAD24 define two additive, interacting branches of the DNA damage checkpoint pathway in budding yeast normally required for Rad53 modification and activation.

@article{TorreRuiz1998RAD9AR,
  title={RAD9 and RAD24 define two additive, interacting branches of the DNA damage checkpoint pathway in budding yeast normally required for Rad53 modification and activation.},
  author={M A de la Torre-Ruiz and Catherine Green and Noel Francis Lowndes},
  journal={The EMBO journal},
  year={1998},
  volume={17 9},
  pages={2687-98}
}
In budding yeast, RAD9 and RAD24/RAD17/MEC3 are believed to function upstream of MEC1 and RAD53 in signalling the presence of DNA damage. Deletion of any one of these genes reduces the normal G1/S and G2/M checkpoint delays after UV irradiation, whereas in rad9Delta-rad24Delta cells the G1/S checkpoint is undetectable, although there is a residual G2/M checkpoint. We have shown previously that RAD9 also controls the transcriptional induction of a DNA damage regulon (DDR). We now report that… CONTINUE READING

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RAD9 and RAD24 define two additive , interacting branches of the DNA damage checkpoint pathway in budding yeast normally required for Rad53 modification and activation .
RAD9 and RAD24 define two additive , interacting branches of the DNA damage checkpoint pathway in budding yeast normally required for Rad53 modification and activation .
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