RAD6 promotes homologous recombination repair by activating the autophagy-mediated degradation of heterochromatin protein HP1.

@article{Chen2015RAD6PH,
  title={RAD6 promotes homologous recombination repair by activating the autophagy-mediated degradation of heterochromatin protein HP1.},
  author={Su Chen and Chen Wang and Luxi Sun and Da-Liang Wang and Lu Chen and Zhuan Huang and Qi Yang and Jie Gao and X Yang and Jian-Feng Chang and Ping Chen and Li Lan and Zhiyong Mao and Fang-Lin Sun},
  journal={Molecular and cellular biology},
  year={2015},
  volume={35 2},
  pages={406-16}
}
Efficient DNA double-strand break (DSB) repair is critical for the maintenance of genome stability. Unrepaired or misrepaired DSBs cause chromosomal rearrangements that can result in severe consequences, such as tumorigenesis. RAD6 is an E2 ubiquitin-conjugating enzyme that plays a pivotal role in repairing UV-induced DNA damage. Here, we present evidence that RAD6 is also required for DNA DSB repair via homologous recombination (HR) by specifically regulating the degradation of heterochromatin… CONTINUE READING
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