RAD51 paralogs: roles in DNA damage signalling, recombinational repair and tumorigenesis.

@article{Suwaki2011RAD51PR,
  title={RAD51 paralogs: roles in DNA damage signalling, recombinational repair and tumorigenesis.},
  author={Natsuko Suwaki and Kerstin Klare and Madalena Tarsounas},
  journal={Seminars in cell & developmental biology},
  year={2011},
  volume={22 8},
  pages={898-905}
}
Chromosomal double-strand breaks (DSBs) have the potential to permanently arrest cell cycle progression and endanger cell survival. They must therefore be efficiently repaired to preserve genome integrity and functionality. Homologous recombination (HR) provides an important error-free mechanism for DSB repair in mammalian cells. In addition to RAD51, the central recombinase activity in mammalian cells, a family of proteins known as the RAD51 paralogs and consisting of five proteins (RAD51B… CONTINUE READING
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