RAD51 localization and activation following DNA damage.

  title={RAD51 localization and activation following DNA damage.},
  author={Madalena Tarsounas and Adelina A. Davies and Stephen C West},
  journal={Philosophical transactions of the Royal Society of London. Series B, Biological sciences},
  volume={359 1441},
The efficient repair of double-strand breaks in DNA is critical for the maintenance of genome stability. In response to ionizing radiation and other DNA-damaging agents, the RAD51 protein, which is essential for homologous recombination, relocalizes within the nucleus to form distinct foci that can be visualized by microscopy and are thought to represent sites where repair reactions take place. The formation of RAD51 foci in response to DNA damage is dependent upon BRCA2 and a series of… CONTINUE READING