RAD51 135G>C polymorphism and risk of familial breast cancer in a South American population.

@article{Jara2007RAD511P,
  title={RAD51 135G>C polymorphism and risk of familial breast cancer in a South American population.},
  author={Lilian Jara and M{\'o}nica Acevedo and Rafael W Blanco and Victor G. Castro and Teresa Bravo and Fernando G{\'o}mez and Enrique Waugh and Octavio Peralta and Elsa Cabrera and Jos{\'e} Luis Reyes and Sandra Ll Ampuero and Patricio Gonzalez-Hormazabal},
  journal={Cancer genetics and cytogenetics},
  year={2007},
  volume={178 1},
  pages={65-9}
}
Several studies have reported that mutations in genes involved in maintenance of genome integrity may be responsible for increased cancer risk. Human RAD51, known to function in DNA repair, interacts with a number of proteins implicated in breast cancer (BC), including BRCA1 and BRCA2. Few studies have investigated the role of RAD51 gene variations in familial BC. To detect potential novel gene defects that may contribute to hereditary BC susceptibility, 143 patients belonging to 143 Chilean… CONTINUE READING

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DNA RepairProcess involves geneRAD51 gene
Human RAD51 , known to function in DNA repair , interacts with a number of proteins implicated in breast cancer ( BC ) , including BRCA1 and BRCA2 .
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