RAD23A negatively regulates RIG-I/MDA5 signaling through promoting TRAF2 polyubiquitination and degradation.

@article{Fang2013RAD23ANR,
  title={RAD23A negatively regulates RIG-I/MDA5 signaling through promoting TRAF2 polyubiquitination and degradation.},
  author={Di-Feng Fang and Kun He and Jie Wang and Rui Mu and Bo Tan and Zhao Jian and Hui-yan Li and Wei Song and Yan Chang and Wei-li Gong and Wei-hua Li and Guan-jun Wang},
  journal={Biochemical and biophysical research communications},
  year={2013},
  volume={431 4},
  pages={686-92}
}
RIG-I/MDA5 plays a pivotal role in innate immunity by detecting intracellular double-stranded RNA (dsRNA) and activating the transcription of type I interferons and proinflammatory factors, but the exactly regulating mechanism of RIG-I/MDA5 signaling remains elusive. In this study, UbL-UBA domain containing protein RAD23A was identified as a negative… CONTINUE READING