RAD-6: pyrimidine synthesis and radiation sensitivity in Caenorhabditis elegans.

@article{Merry2014RAD6PS,
  title={RAD-6: pyrimidine synthesis and radiation sensitivity in Caenorhabditis elegans.},
  author={Alyce Merry and Mengmeng Qiao and Martin Hasler and Patricia E. Kuwabara},
  journal={The Biochemical journal},
  year={2014},
  volume={458 2},
  pages={343-53}
}
The Caenorhabditis elegans rad-6 (radiation-sensitive-6) mutant was isolated over 25 years ago in a genetic screen that identified mutants with enhanced sensitivity to DNA damaging agents. In the present paper we describe the molecular identification of the rad-6 gene and reveal that it encodes the bifunctional UMP synthase protein, which carries catalytic activities for OPRTase (orotate phosphoribosyltransferase) and ODCase (orotate monophosphate decarboxylase), key enzymes in the de novo… CONTINUE READING
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