RACKI induces chemotherapy resistance in esophageal carcinoma by upregulating the PI3K/AKT pathway and Bcl-2 expression

Abstract

Introduction Accumulating evidence indicates that RACK1 is involved in the progression of tumors. We aimed to evaluate the function of RACK1 in esophageal squamous cell carcinoma (ESCC) and its role in the mechanism of chemotherapy resistance. Materials and methods Transfected ESCC cell lines with plasmids expressed shRACK1 or open reading frame (ORF… (More)
DOI: 10.2147/OTT.S152818

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