RACK1 recruits STAT3 specifically to insulin and insulin-like growth factor 1 receptors for activation, which is important for regulating anchorage-independent growth.

@article{Zhang2006RACK1RS,
  title={RACK1 recruits STAT3 specifically to insulin and insulin-like growth factor 1 receptors for activation, which is important for regulating anchorage-independent growth.},
  author={Weizhou Zhang and Cong Susan Zong and Ulrich Hermanto and Pablo L{\'o}pez-Bergami and Ze'ev A Ronai and L Wang},
  journal={Molecular and cellular biology},
  year={2006},
  volume={26 2},
  pages={413-24}
}
Current understanding of the activation of STATs is through binding between the SH2 domain of STATs and phosphotyrosine of tyrosine kinases. Here we demonstrate a novel role of RACK1 as an adaptor for insulin and insulin-like growth factor 1 receptor (IGF-1R)-mediated STAT3 activation specifically. Intracellular association of RACK1 via its N-terminal WD domains 1 to 4 (WD1-4) with insulin receptor (IR)/IGF-1R is augmented upon respective ligand stimulation, whereas association with STAT3 is… CONTINUE READING

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