RACK1 promotes neurite outgrowth by scaffolding AGAP2 to FAK.

@article{Dwane2014RACK1PN,
  title={RACK1 promotes neurite outgrowth by scaffolding AGAP2 to FAK.},
  author={Susan Dwane and Edel Durack and Rosemary O'connor and Patrick A. Kiely},
  journal={Cellular signalling},
  year={2014},
  volume={26 1},
  pages={
          9-18
        }
}
RACK1 binds proteins in a constitutive or transient manner and supports signal transmission by engaging in diverse and distinct signalling pathways. The emerging theme is that RACK1 functions as a signalling switch, recruiting proteins to form distinct molecular complexes. In focal adhesions, RACK1 is required for the regulation of FAK activity and for integrating a wide array of cellular signalling events including the integration of growth factor and adhesion signalling pathways. FAK is… CONTINUE READING
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