RACK1 inhibits colonic cell growth by regulating Src activity at cell cycle checkpoints

@article{Mamidipudi2007RACK1IC,
  title={RACK1 inhibits colonic cell growth by regulating Src activity at cell cycle checkpoints},
  author={Vidya Mamidipudi and Navdeep S. Dhillon and Toufan Parman and Leonard D. Miller and Kelly C. Lee and Christine A. Cartwright},
  journal={Oncogene},
  year={2007},
  volume={26},
  pages={2914-2924}
}
Previously, we showed that Src tyrosine kinases are activated early in the development of human colon cancer and are suppressed as intestinal cells differentiate. We identified RACK1 as an endogenous substrate, binding partner and inhibitor of Src. Here we show (by overexpressing RACK1, depleting Src or RACK1 and utilizing cell-permeable peptides that perturb RACK1's interaction with Src) that RACK1 regulates growth of colon cells by suppressing Src activity at G1 and mitotic checkpoints, and… CONTINUE READING
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