RACK1 affects morphine reward via BDNF.

  title={RACK1 affects morphine reward via BDNF.},
  author={Lihong Wan and Yizhou Xie and Lan Su and Yanyou Liu and Yuhui Wang and Zhengrong Wang},
  journal={Brain research},
Chronic morphine addiction may trigger functional changes in the mesolimbic dopamine system, which is believed to be the neurobiological substrate of opiate addiction. Brain derived neurotrophic factor (BDNF) has been implicated in addiction-related pathology in animal studies. Our previous studies have shown that RACK1 is involved in morphine reward in mice. The recent research indicates nuclear RACK1 by localizing at the promoter IV region of the BDNF gene and the subsequent chromatin… CONTINUE READING

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