RAC2-P38 MAPK-dependent NADPH oxidase activity is associated with the resistance of quiescent cells to ionizing radiation.

@article{Pei2017RAC2P38MN,
  title={RAC2-P38 MAPK-dependent NADPH oxidase activity is associated with the resistance of quiescent cells to ionizing radiation.},
  author={Hailong Pei and Jian Zhang and Jing Nie and Nan Ding and Wentao Hu and Junrui Hua and Ryoichi Hirayama and Yoshiya Furusawa and Cuihua Liu and Bingyan Li and Tom K. Hei and Guangming Zhou},
  journal={Cell cycle},
  year={2017},
  volume={16 1},
  pages={113-122}
}
Our recent study showed that quiescent G0 cells are more resistant to ionizing radiation than G1 cells; however, the underlying mechanism for this increased radioresistance is unknown. Based on the relatively lower DNA damage induced in G0 cells, we hypothesize that these cells are exposed to less oxidative stress during exposure. As a catalytic subunit of NADPH oxidase, Ras-related C3 botulinum toxin substrate 2 (RAC2) may be involved in the cellular response to ionizing radiation. Here, we… CONTINUE READING
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